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There is quite a bit of missing information here.

a. Lets assume your pressure is 1 atm.
b. Lets also assume you are distilling methanol and water.
c. Lets assume your theoretical plate efficiency is 100%
d. Lets ALSO assume your initial concentration is 0.1 mol% methanol.

Given these condition it takes about 1.25 theoretical plates to distill it to about 49 mol%.

The number of plates depends heavily on the initial concentration.
Working backwards from 49mol%, exactly one stage would place you at an initial concentration of about 8%. Exactly two would place you at about 1 mol%.

See also the McCabe Thiele method: http://en.wikipedia.org/wiki/McCabe-Thiele_method

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Q: If your first distillate was 49 mole percent methanol how many theoretical plates were in your distillation setup?
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