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If they're mixed, but remain separate (as in a solution) then the answer is no. But if the two chemicals undergo a chemical reaction with each other then at least one new substance will be formed; if there are by-products from the reaction, then more than one new substance will be produced.

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What are the chemicals called when they are mixed?

a solution is two substance mixed together


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When a chemical change is in place does no new substance form?

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