aerobic
The end product of the breakdown of pyruvic acid in aerobic conditions is acetyl-CoA, which enters the citric acid cycle. In anaerobic conditions, pyruvate is reduced to lactate or fermented to produce ethanol.
Acetyl-CoA is the metabolite that enters the citric acid cycle and is formed in part by the removal of a carbon from one molecule of pyruvate through a process called pyruvate decarboxylation.
The enzyme CoA catalyzes the reaction between pyruvic acid and CoA to form acetyl-CoA in the mitochondria. This is a crucial step in the conversion of glucose to energy in the form of ATP through the process of cellular respiration. Acetyl-CoA enters the citric acid cycle to produce more ATP.
The citric acid cycle begins with acetyl-CoA and ends with oxaloacetate.
The enzyme that converts pyruvate into acetyl-CoA is pyruvate dehydrogenase. This multienzyme complex is responsible for catalyzing the conversion of pyruvate into acetyl-CoA, which is a key step in the metabolism of carbohydrates to produce energy.
The sequence of events in aerobic respiration is: glycolysis, formation of acetyl CoA, the Krebs cycle, the electron transport chain.
The products of acetyl CoA formation from a molecule of pyruvate are acetyl CoA, NADH, and carbon dioxide. This process occurs during the mitochondrial pyruvate dehydrogenase complex reaction, where pyruvate is converted to acetyl CoA by a series of enzymatic reactions.
The end product of the breakdown of pyruvic acid in aerobic conditions is acetyl-CoA, which enters the citric acid cycle. In anaerobic conditions, pyruvate is reduced to lactate or fermented to produce ethanol.
The molecule that serves as the common branch point for either the anaerobic or aerobic pathway is pyruvate. Depending on the availability of oxygen, pyruvate can either be converted into acetyl-CoA to enter the aerobic pathway (Krebs cycle or citric acid cycle) or undergo fermentation in the absence of oxygen.
Acetyl-CoA is produced from the oxidation of pyruvate in the mitochondria during the process of aerobic respiration. Pyruvate is first converted to acetyl-CoA by the pyruvate dehydrogenase complex, which involves a series of enzymatic reactions. Acetyl-CoA is a key molecule that enters the citric acid cycle to generate ATP through the electron transport chain.
Acetyl CoA formation occurs mainly in the mitochondrial matrix of cells as a result of the breakdown of carbohydrates, fats, and proteins. It is a key intermediate in metabolism, serving as a central molecule in the synthesis of fatty acids and energy production through the TCA cycle.
The formation of acetyl-CoA
Acetyl CoA
Acetyl CoA is the compound that enters the Kreb's cycle.
Proc. Nati. Acad. Sci. USA Vol. 87, pp. 6097-6101, August 1990 Biochemistry Some protists are aerobic and contain mitochondria and some are anaerobic, containing hydrogenosomes. Although some have no membrane-bounded organelles of energy metabolism (i.e. mitochondria used for cellular respiration), others contain hydrogenosomes, unusual organelles surrounded by two membranes (1, 2). These organelles are the site of oxidative decarboxylation of pyruvate with the formation of acetyl-CoA. This process is mediated by pyruvate:ferredoxin oxidoreductase and is coupled to anaerobic formation of H2 catalyzed by hydrogenase. This is a great reading for those that would like to know more about anaerobic protists!
No, acetyl CoA cannot be directly converted to glucose in the body.
No, acetyl CoA cannot be directly used to produce glucose.