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  1. Methylationof 3-propylpyrazole-5-carboxylic acid ethyl ester with hot dimethyl sulfate
  2. Hydrolysiswith aqueous NaOH to free acid
  3. Nitrationwith oleum/fuming nitric acid
  4. Carboxamideformation with refluxing thionyl chloride/NH4OH
  5. Reductionof nitro group to amino
  6. Acylationwith 2-ethoxybenzoyl chloride
  7. Cyclization
  8. Sulfonationto the chlorosulfonyl derivative
  9. Condensationwith 1-methylpiperazine

10. Conversion of glucose to ethanol via fermentation.





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