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Purine is weakly basic in nature (pKa 2.5). 13C NMR studies of the protonated purine indicate the presence of all three protonated forms of purine in solution. However, the predominant cation is formed by protonation at N-1.[J. Org. Chem. year: 1965, Vol.: 30, page: 1110] In strong acids, dication is formed via protonation at N-1 and on the five membered ring.

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What is the least basic nitrogen atom in purine?

The least basic nitrogen atom in purine is the N9 atom.


Why isoquinoline is more basic then quinoline?

Isoquinoline is more basic than quinoline due to the presence of an extra nitrogen atom in the heterocyclic ring. This extra nitrogen can accept a proton more readily, making isoquinoline more basic. The lone pair of electrons on the additional nitrogen atom is more available for protonation compared to the lone pair on the nitrogen in quinoline.


Which is more basic pyrrole or indole?

Indole is more basic than pyrrole due to the presence of the nitrogen atom in the benzene ring of the indole structure. The lone pair of electrons on the nitrogen atom in indole makes it more basic compared to pyrrole, which lacks this nitrogen atom in the benzene ring.


Which is more basic pyridine or quinoline?

Pyridine is more basic than quinoline. This is because the nitrogen atom in pyridine is more readily available to accept a proton compared to the nitrogen in quinoline due to the presence of an additional ring in quinoline which delocalizes the lone pair of electrons on the nitrogen atom, making it less basic.


Why Imidazole is more basic than pyrazole?

Imidazole is more basic than pyrazole because it has a lone pair of electrons on the nitrogen atom that can more easily donate to accept a proton, compared to pyrazole which has both nitrogen atoms in a conjugated system, making it less available to donate electrons. The presence of the nitrogen lone pair in imidazole makes it more nucleophilic and therefore more basic.

Related Questions

Is nitrogen a base?

A basic compound that contains nitrogen, such as a purine or pyrimidine. A basic compound that contains nitrogen, such as a purine or pyrimidine.


What is the least basic nitrogen atom in purine?

The least basic nitrogen atom in purine is the N9 atom.


What are the elements of a nitrogenous base?

A basic compound that contains nitrogen, such as a purine or pyrimidine. A basic compound that contains nitrogen, such as a purine or pyrimidine.


Where a purine base only pairs with a pyrimidine?

nitrogen


Purine nucleotides mainly differ from pyrimidine nucleotides in their number of?

Purine nucleotides differ from pyrimidine nucleotides in their structure due to the number of nitrogen-containing rings they have. Purine nucleotides have a double-ring structure, while pyrimidine nucleotides have a single-ring structure.


Why isoquinoline is more basic then quinoline?

Isoquinoline is more basic than quinoline due to the presence of an extra nitrogen atom in the heterocyclic ring. This extra nitrogen can accept a proton more readily, making isoquinoline more basic. The lone pair of electrons on the additional nitrogen atom is more available for protonation compared to the lone pair on the nitrogen in quinoline.


Which is more basic pyrrole or indole?

Indole is more basic than pyrrole due to the presence of the nitrogen atom in the benzene ring of the indole structure. The lone pair of electrons on the nitrogen atom in indole makes it more basic compared to pyrrole, which lacks this nitrogen atom in the benzene ring.


Which is more basic pyridine or quinoline?

Pyridine is more basic than quinoline. This is because the nitrogen atom in pyridine is more readily available to accept a proton compared to the nitrogen in quinoline due to the presence of an additional ring in quinoline which delocalizes the lone pair of electrons on the nitrogen atom, making it less basic.


Why Imidazole is more basic than pyrazole?

Imidazole is more basic than pyrazole because it has a lone pair of electrons on the nitrogen atom that can more easily donate to accept a proton, compared to pyrazole which has both nitrogen atoms in a conjugated system, making it less available to donate electrons. The presence of the nitrogen lone pair in imidazole makes it more nucleophilic and therefore more basic.


Is transversion of t to an equivalent to transversion of t to g For example is T961a the equivalent of T961g?

Transversion is the substitution of a purine for a pyrimidine and vice versa. The nitrogen bases adenine (A) and guanine (G) are purines and the nitrogen bases thymine (T) and cytosine (C) are pyrimidines. The transversion of T to A is equivalent to the transversion of T to G in that a pyrimidine, T, is substituted by either the purine A or the purine G. T961a is not equivalent to T961g.


What does purine mean?

A purine is a nucleotide in DNA that only has 1 ring.


When purine base only pairs with a pyrimidine?

This is a basic principle of DNA base pairing called Chargaff's rule. Adenine (purine) pairs with thymine (pyrimidine), while guanine (purine) pairs with cytosine (pyrimidine). This complementary base pairing is essential for the double-stranded structure of DNA.