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The main difference between sec-butyl and tert-butyl groups lies in their branching structure. The sec-butyl group has a linear structure with one branch, while the tert-butyl group has a more compact, branched structure with three branches. This difference affects their chemical properties and reactivity. The tert-butyl group is more sterically hindered due to its bulky structure, making it less reactive compared to the sec-butyl group. Additionally, the tert-butyl group is more stable and less prone to undergo reactions compared to the sec-butyl group.

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