What are the physicochemical parameters that influence the stability of benzylpencillin?

Answer 1

Comparison of intravenous penicillin G and oral doxycycline for treatment of Lyme neuroborreliosis; Karlsson M et al.; To compare the efficacy of oral doxycycline and IV penicillin G for the treatment of neuroborreliosis, we randomized consecutive patients with Lyme neuroborreliosis to receive either IV penicillin G (3 g q 6 h) or oral deoxycycline (200 mg q 24 h) for 14 days . All patients had antibodies against Borrelia burgdorferi in serum, CSF, or both, or had a positive CSF culture . Twenty-three patients randomized to penicillin G and 31 patients to doxycycline were included in the study . All patients improved during treatment, and there were no significant differences between the two treatment groups in patient scoring, CSF analysis, or serologic and clinical follow-up during 1 year . There were no treatment failures, although one patient in each treatment group was re-treated because of residual symptoms . In conclusion, oral doxycycline is an adequate and cost-effective alternative to IV penicillin for the treatment of Lyme neuroborreliosis.