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Trichloroacetic acid is widely used in biochemistry for the precipitation of macromolecules such as proteins, DNA and RNA. Its sodium salt is used as a weedkiller. Solutions containing trichloroacetic acid as an ingredient are used for cosmetic treatments such as chemical peels and tattoo removal and the treatment of warts, including genital warts. It can kill normal cells as well. It is considered safe for use for this purpose during pregnancy[3].
Salts of trichloroacetic acid are called trichloroacetates. Reduction of trichloroacetic acid results in dichloroacetic acid, a pharmacologically active compound that shows promise for the treatment of cancer.
Source: Wikipedia
What else can I help you with?
What reagent used to test heller's test in protein precipitation?
Heller's test uses strong acids, such as nitric acid or trichloroacetic acid, to precipitate proteins. The protein precipitation occurs due to denaturation of the proteins in the presence of the acid, leading to their insolubility and precipitation.
Why concentrated trichloroacetic acid becomes cold when add water?
When concentrated trichloroacetic acid is added to water, it undergoes a highly exothermic reaction. This rapid release of heat causes the surrounding area to cool down, giving the impression that the mixture is becoming cold. It is important to add acid to water slowly to control the amount of heat released and prevent splashing.
What is an example of a corrosive acid?
One example of a corrosive acid is hydrochloric acid. It is a strong acid that can cause damage to skin, eyes, and mucous membranes upon contact. It is commonly used in various industries for cleaning, pickling, and pH control.
How do you create tri chloro acetic acid from acetic acid?
Trichloroacetic acid (TCA) can be obtained by reacting acetic acid with chlorine in the presence of a catalyst such as sulfuric acid or phosphorus pentachloride. The reaction involves substitution of three chlorine atoms for three hydrogen atoms on the acetic acid molecule. The reaction is typically conducted under controlled conditions due to the corrosive nature of TCA.
Why trichloroacitic acid is stronger than dichloro and monochloro acitic acid?
Trichloroacetic acid is stronger than dichloroacetic and monochloroacetic acids because it has more chlorine atoms attached to the central carbon, making it more electron-withdrawing and acidic. This extra electron withdrawal stabilizes the conjugate base formed after donating a proton, leading to stronger acidity.
What is the chemical formula of trichloroacetic acid?
The chemical formula of trichloroacetic acid is C2HCl3O2.
Why do you use trichloroacetic acid in glycogen extraction?
Trichloroacetic acid is used in glycogen extraction to precipitate proteins from the sample. This helps to separate the glycogen from other cellular components before further purification steps. Additionally, trichloroacetic acid helps to denature and inactivate enzymes that may degrade the glycogen during extraction.
What is the purpose of Trichloroacetic acid in DNA extraction?
Trichloroacetic acid is used in DNA extraction to precipitate proteins and other contaminants from the DNA solution. This helps to separate the DNA from other cellular components, making it easier to isolate and purify the DNA for downstream applications.
What reagent used to test heller's test in protein precipitation?
Heller's test uses strong acids, such as nitric acid or trichloroacetic acid, to precipitate proteins. The protein precipitation occurs due to denaturation of the proteins in the presence of the acid, leading to their insolubility and precipitation.
How can you get rid of xanthelasma palpebrarum?
Xanthelasma can be removed with a trichloroacetic acid peel, surgery, laser, or cryotherpay.
How do you make Trichloroacetic acid 10 percent solution?
dissolve 10g of TCA in 100ml distilled water.
Why is trichloroacetic acid used in protease assay?
Trichloroacetic acid is used in protease assays as a protein precipitation agent. It helps to denature proteins and disrupt protein-protein interactions, allowing for the measurement of protease activity in a sample by separating the proteins from the reaction mixture.
Why concentrated trichloroacetic acid becomes cold when add water?
When concentrated trichloroacetic acid is added to water, it undergoes a highly exothermic reaction. This rapid release of heat causes the surrounding area to cool down, giving the impression that the mixture is becoming cold. It is important to add acid to water slowly to control the amount of heat released and prevent splashing.
What acid is in an apple?
Carboxylic acid Formic acid Acetic acid Chloroacetic acid Dichloroacetic acid Trichloroacetic acid Trifluoroacetic acid Oxalic acid Benzoic acid
What is an example of a corrosive acid?
One example of a corrosive acid is hydrochloric acid. It is a strong acid that can cause damage to skin, eyes, and mucous membranes upon contact. It is commonly used in various industries for cleaning, pickling, and pH control.
Explain why tricynomethane has value pka 5?
Trichloroacetic acid (also known as trichloroacetic acid or TCA) has a pKa value of approximately 5 due to its strong acidity, which is influenced by the electronegative chlorine atoms attached to the carbon atom. These chlorine atoms stabilize the negative charge that forms on the conjugate base when the acid donates a proton. The inductive effect of the chlorine atoms enhances the acid's ability to dissociate, resulting in a lower pKa value compared to many other carboxylic acids. Thus, TCA is considered a relatively strong acid among organic compounds.
What are the alternatives to dermabrasion?
A variety of other skin resurfacing techniques are available and include chemical (phenol or trichloroacetic acid, TCA) peels and laser (CO2 and Erbium) resurfacing
