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What is a rat's oral LD50 for water?

Updated: 6/2/2024
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10y ago

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This would be impossible to achieve.

Excessive consumption would lead to vomiting, preventing any futher ingestion of water.

Edit: the person that initially answered this is wrong. Water does have an LD50, and for rats it's 90 ml/kg. It should be something similar to that for humans. Here's a woman that died in a water drinking contest from water intoxification: http://www.msnbc.msn.com/id/16614865/

This has nothing to do with the presence of water, but rather the lack of electrolytes such as salt. Drinking water uses up your body's "supply" of salt, and if it gets used up completely, your brain can no longer transmit electrical signals and you die. If you get a steady supply of salt with the water, you won't have any problems no matter how much water you drink, but as the first answer said, there is a limit to how much water you can drink before your body refuses to take any more, and anything you drink just gets vomited out.

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10y ago
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2w ago

The oral LD50 of water for rats is estimated to be greater than 90 mL/kg. This means that a rat would need to consume a very large amount of water to reach a dose that would be lethal to half of the population.

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12y ago

Oral LD50 in rats is 5045 mg/kg for 2-propanol, the usual isomer when isopropanol is referred to.

Oral LD50 in rats is 1870 mg/kg for 1-propanol, the other isomer.

No easily found data on humans on the internet but just for an interesting comparison, LD50 for rats is 7060 mg/kg for ethanol.

Data from MSDS published by manufacturers.

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10y ago

According to Wikipedia, that value is >90 or >90,000 ml/kg

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