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Copper(II) hydroxide reacts with a solution of ammonia to form a deep blue solution consisting of the [Cu(NH3)4]2+ complex ion. Copper(II) hydroxide in ammonia solution, known as Schweizer's reagent, possesses the interesting ability to dissolve cellulose. This property led to it being used in the production of rayon, a cellulose fiber.

Since copper(II) hydroxide is mildly amphoteric, it dissolves slightly in concentrated alkali, forming [Cu(OH)4]2-.

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