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Morphine is obtained from the latex of opium poppy seed pods. The opiod oxycodone is synthesized from thebaine, another alkaloid found in opium. Oxycodone and morphine differ in their mode of metabolism. Unlike morphine, oxycodone is metabolized by enzymes in the liver that detoxify a number of prescription drugs. One benefit of oxycodone is that it has fewer side effects than morphine. The latter drug brings on a very strong feeling of pleasure and euphoria. There is pleasure after taking oxycodone, but fewer euphoric side effects than from taking morphine. This should cause oxycodone to be less addictive. Street availability is another difference between oxycodone and morphine. Since morphine is so rarely prescribed for home use, it is not commonly sold on the street. There are large numbers of prescriptions filled for oxycodone in the United States. The drug is available in a slow-release form called OxyContin® that is highly popular with recreational drug users.

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