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What is the positive inside rule?

Updated: 4/28/2022
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The positive inside rule is a general rule for membrane proteins. Because of the mechanism involved in transmembrane domain insertion (regions of the protein which cross the membrane), membrane proteins tend to have more residues which can take on a positive charge on the inside of their cells. So, almost all, if not all membrane proteins have more solvent exposed Lysine and Arginine residues on the sides of the transmembrane domains which rest inside of the cell in comparison to the number which rest on the outside of the cell.

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Q: What is the positive inside rule?
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Is there a general rule that you must always follow when multiplying or dividing an inequality by a negative value?

positive and positive are positive positive and negative are negative negative and negative is positive


What causes the inside of neuron becomes positive?

Outside a neuron, there are mostly sodium ions but some potassium ions. Inside the neuron, there are only potassium ions. Since both sodium and potassium are positive ions, and they are in a higher concentration outside the cell, that makes the outside have a more positive charge than the inside. But for all intents and purposes, the outside is positive, and the inside is negative. When the sodium ions (Na+) rush into the cell during depolarization, it causes the concentration of positive ions inside the cell to go WAY up, making the inside more positive than the outside. This means that the outside is now negative and the inside now positive.


What is the rule for multiplying and dividing with the same sign?

The answer is positive.


What is the rule in dividing integers?

The rule in dividing integers is to divide the absolute values. Two positive integers or two negative integers equals positive product. If one integer is positive and the other is negative, the product is negative.


What is the rule in multiplying integers with the same sign?

When you multiply two integers of the same sign, the answer is always positive. A positive times a positive is positive and a negative times a negative is positive.


Rule for multiplying integers?

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Why does a negative times a negative equals a positive?

It is a rule in math!