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The circulatory system, which includes the heart and blood vessels, is most involved in the transportation of oxygen in the human body. This system is responsible for pumping oxygen-rich blood from the lungs to the rest of the body's tissues and cells, where oxygen is utilized in cellular respiration to produce energy. Additionally, the circulatory system also collects carbon dioxide, a waste product of this process, and transports it back to the lungs to be exhaled.

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