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Why are weak acids better absorbed in the small intestine than the stomach despite their high degree of ionization?
Wiki User
∙ 7y ago
There pH at the surface of the intestinal mucosa is around 5.3. This is lower than the bulk pH in the small intestine's lumen. Also, the large mucosal surface area provides a large area for absorption in the small intestine. This large surface area compensates for the low degree of unionization for weakly acidic drugs. When the nonionized form of the drug is removed, more cationic and anionic species will combine to yield the nonionized form so a certain concentration of the nonionized drug will always be maintained until the end of the absorption process.
Wiki User
∙ 7y ago
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What is role of HCL in the stomach?
HCL breaks down proteins into there constituent amino acids so they can be absorbed in the small intestine.
Where does digestive enzymes work?
Digestive enzymes work in the mouth, stomach and small intestine. Enzymes break down food so that it can be absorbed by the body.
What organ is involved with the deamination of amino acids?
Through researching this question i have found out that the stomach absorbs proteins which are made up of amino acids. After the stomach amino acids are then absorbed by the duodenum ( a buffer for acids in the stomach in small intestine, called sodium bicarbonate).
What is the pH of stomach and small intestine?
Your stomach empties its contents into the small intestine. Here, digestive fluid containing bicarbonate ions surrounds the food.
A nonenteric film-coated tablet is meant to dissolve in?
either the stomach or the intestine
Is aspirin absorbed in the stomach or intestines?
Aspirin is absorbed both in the stomach and the small intestine , for the former the cause lies beyond the fact that the gastric PH (1.5-2.5) is lower than the pka of aspirin (3.5) such that the ionization of aspirin is so much limited and the unionized and subsequently the lipophilicity of aspirin increases so that it's easily absorbed into the gastric mucosal cells. for the latter , aspirin absorption is due to the large absorptive surface area of the small intestine despite the fact that the intestinal PH is higher than the pka of aspirin , but still the surface area help absorption of the unionized fraction of aspirin.
During digestion where is water absorbed?
Large Intestine
Where is Ibuprofen absorbed in the stomach or intestine?
Ibuprofen is mostly absorbed in the duodenum (small intestine). It cannot be absorbed through the lining of the stomach due to its low solubility in water and the low pH of stomach acid (since ibuprofen dissolves in water better at higher pH's).
What a long folded tube inside the body attached to the stomach where nutrients in the food are absorbed?
Small intestine is where 90% of nutrients are absorbed.
Where in the digesitve system is absorption?
alcohol and aspirin are absorbed in the stomach, everything else is absorbed in the small intestine and excess water and vitamins k and b are absorbed in the large intestine.
Organ were digested food is absorbed?
Food is broken down or digested in the stomach but the nutrients are not absorbed in the stomach. Nutrients from digested food are primarily absorbed in the small intestine.
What happen when enzymes from the stomach enters the small intestine?
food will be absorbed
Where is alcohol absorbed?
When you take a drink, about 20 percent of the alcohol is absorbed in your stomach; the remaining 80 percent is absorbed in your small intestine.
What is the long tube inside the body attached to the stomach where nutrients in the food are absorbed?
Small intestine is where 90% of nutrients are absorbed.
What is the folded tube inside the body attached to the stomach where nutrients in the food are absorbed.?
Small intestine is where 90% of nutrients are absorbed.
Where does most chemical digestion take place and nutrients are absorbed into the blood?
chemical digestion takes place in the small intestine large intestine,mouth and stomach. Nutrients are absorbed in the small intestine and minerals in the large intestine.
What percentage of alcohol is absorbed through small intestine?
The percentage of alcohol that is absorbed through the small intestines is 80%. The remaining 20% of alcohol consumed is absorbed through the stomach.
