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The nitrogen group is electron withdrawing and therefore deactivates the ring. So, friedel crafts reaction will not take place.
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∙ 11y ago
Anonymous
This is because, the the lewis acids ie. AlCl3 or FeCl3 readily interacts with the lone on nitrogen in pyridine due to which electrophile ie. CH3CO+ or CH3CH2+ is not get generated and rxn doesn't happens. And instead of desired product we something else that we don't want...
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Why aniline doesn't under go friedal craft reaction?
Aniline doesnt undergo friedel craft rxn because the reagent AlCl3,(the lewis acid which is used as a catalyst in friedel crafts reaction).being e- deficient acts as lewis base and attacks on the lone pair of nitrogen present in aniline & aniline forms a salt with Aluminium chloride. Due to this nitrogen atom of aniline acquires a positive charge and hence acts as a strong deactivating group and thus doesn 't allow the reaction to take place.In other cases ther is no such reaction.
Why are only monosubstitution products obtained in the acylation of the substrate compounds chosen in friedel crafts acylation?
because the group added is a withdrawing group that deactivates the ring
How do we convert benzene into acetophenone?
To synthesize acetophenone from benzene, you just need to add the aldehyde to the benzene ring. This can be done via a Friedel-Crafts acylation. The reagents are an acid chloride (acetyl chloride in this case) and AlCl3 (stoichiometric).
What is acetylation?
Acylation is a reaction in which an acyl group becomes attached to some structural unit in a molecule. Examples include the Friefel-Crafts acylation adn the conversio of amines to amides.
What has arsenicosis got to do with Hephaestus?
Arsenic is a metal, and Hephaestus crafts with metals.
What has the author C M Jephcott written?
C. M. Jephcott has written: 'Friedel and Crafts' reaction in the pyridine series'
What is important questions of chemistry part 2 fsc rwp board?
Friedel–Crafts reaction
Friedel Crafts acylation of naphthalene depend on type of solvent used?
Friedel Crafts acylation of naphthalene
Why is aluminum chloride used in large excess in Friedel-Crafts reactions?
To ensure there's enough of it to allow the reaction to go to completion.
What is the Reaction of cumene and acetyl chloride in the presence of aluminum chloride?
The name of this reaction is Friedel-Crafts acylation. It should have a major product adding a ketone at the para position with regard to the isopropyl of the cumene.
What has the author Jacob Meyer Zeavin written?
Jacob Meyer Zeavin has written: 'Preparation of some monoderivatives of benzoic anhydride and their reaction with Friedel-Crafts' synthesis'
Why aniline doesn't under go friedal craft reaction?
Aniline doesnt undergo friedel craft rxn because the reagent AlCl3,(the lewis acid which is used as a catalyst in friedel crafts reaction).being e- deficient acts as lewis base and attacks on the lone pair of nitrogen present in aniline & aniline forms a salt with Aluminium chloride. Due to this nitrogen atom of aniline acquires a positive charge and hence acts as a strong deactivating group and thus doesn 't allow the reaction to take place.In other cases ther is no such reaction.
Explain why the Friedel-Crafts reaction of benzene plus n-propyl chloride in the presence of AlCl3 gives mostly isopropylbenzene?
rearrangemet because primary carbocations cannot form
What are the catalysts used in friedel-crafts reactions instead of stannic chloride?
aluminum chloride
What is the use of aluminium chloride?
The most important application is to use AlCl3 as catalyst in organic chemistry (as an example for Friedel-Crafts reaction); other applications are: - preparation of aluminium in laboratory - petroleum industry - rubber industry
What has the author George A Olah written?
George A. Olah has written: 'A Life Of Magic Chemistry' 'Friedel-Crafts chemistry' -- subject(s): Friedel-Crafts reaction 'Carbonium ions' -- subject(s): Carbonium ions 'Halonium ions' -- subject(s): Halonium ions 'Superelectrophiles and their chemistry' -- subject(s): Organic compounds, Chemical affinity, Superelectrophiles, Synthesis 'Hypercarbon chemistry' -- subject(s): Organometallic chemistry, Carbonium ions
In Freidal craft reactions what is the role of Lewis acids?
Lewis acids help in the generation of electrophiles in Friedel Crafts reactions.
