How many miles can a Ford e150 with a V6 engine go?

Answer 1

No set answer to this. The mileage you get out of a vehicle depends on the quality of workmanship which went into the vehicle, how well the vehicle is maintained, how heavily the vehicle is worked, the environment in which the vehicle is operated and stored, etc.

rconaway - Although this answer is correct, I can give you a better baseline. Assuming that you are running synthetic oil, a really good oil filter like a Mobil 1, change the oil every 10K miles or less, and don't over-rev the engine by driving at 90mph everywhere, and have 80% or more highway miles, I would guess you will get at least 450K miles. However, minor maintenance on that engine is going to include oil pan and rear seal leaks at over 200,000 miles, intake gasket leaks, and possible rear-differential wear. If you use synthetic in the tranny also, it should last the life of the engine. Mine is at 260,000 miles and has compression readings that are within a few percent of new. If you aren't running synthetic oils, change now, put a really good oil filter on there like a Mobile 1 filter, then watch the oil after 500 miles because it will clean out your engine. If it starts getting dirty, change it again, fast. After 2 oil changes, you will have cleaned the engine and should get years more life out of it.