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Unlikely, Squanto died under mysterious circumstances. His only recorded symptom was a nose bleed. his condition is sometimes referred to as "Indian fever." It is very unlikely that it was small pox. Squanto had been exposed to many Europeans during his lifetime. He traveled to England and Spain. It seems that if small pox was going to kill him, it would have done so long ago.

From Mayflower History.comOn one trip to trade for some corn seed for the subsequent growing season, he went with Governor Bradford south on the ocean-side of Cape Cod, and they pulled into Manamoyick Bay because of dangerous weather conditions. There, in November 1622, Squanto's nose began to bleed. He told Governor Bradford it was a sign among the Indians of death. He asked Bradford to pray for him so that he could go to the Englishman's God in Heaven when he died, and asked Bradford to give various things as gifts to his English friends back at Plymouth. Within a few days, he was dead. From Bradford's History of the English Settlement"Here Bay Squanto fell ill of Indian fever, bleeding much at the nose,--which the Indians take as a symptom of death,--and within a few days he died. He begged the Governor to pray for him, that he might go to the Englishman's God in heaven, and bequethed several of his things to his English friends, as remembrances. His death was a great loss."
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13y ago

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