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No, you cannot use a Windows "Program" (application) on a Mac. If it ends with .exe then it can only be opened/used with a Windows OS. And no you can't use an Apple OS program on a Windows OS.

You can now use Apples "Boot Camp" program to make a partition on the Mac computer to use a Windows OS now. Or you can use something like Parallels, VM Ware, etc, to "emulate" a Windows OS on a Mac.

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