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While prolonged use of a computer is associated with eye strain, the irritation normally occurs as a result of muscle fatigue (tiring of the small orbital muscles which articulate the eye, and the ciliary muscles which govern focus by altering the shape of the eye's lens). Unlike when viewing television or a cinema screen, use of a computer entails proximity to the visual device, and the need to focus intently upon parts of it (in order to read, for instance). Just like reading a book, long periods of intent staring can tire the eyes. While using a computer, we also tend to blink less often which can lead to dehydration and irritation of the eye's surface; blinking serves the function of cleaning and moistening.

The eye itself may be irritated, but the optic nerve is not physically influenced by this.

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