No, it probably can't. You can try it if you want.
Older .exe files are not going to work with windows 7. You can use Virtual PC to run applications working under windows xp but not working under windows 7.
ISA devices
as its new, it will work for windows 7
Xp mode
Yes, Dungeons and Dragons Online will work on Windows 7.
Yes, standard mouse does work with Windows 7.
Yes - Open Office will work with Windows 7.
Yes, the Warcraft series of RTS games should work fine in Windows 7. The MMORPG World of Warcraft will definitely work in Windows 7.
Windows 7 will work on a recent Mac (See links below).
It will definitely work on windows 9000 but I'm not sure about windows 7
Yes, it works perfect in Windows 7.
Yes it does! I play it on windows 7 :)