To connect the Roland SP-606 to FL Studio (Fruity Loops), use a USB cable to connect the SP-606 to your computer, ensuring it’s recognized as an audio interface. In FL Studio, go to the Audio settings and select the SP-606 as your input/output device. You can then create a new audio track or use the sampler to import sounds from the SP-606 or record directly from it. Make sure to set the appropriate MIDI settings if you plan to use it for triggering samples or controlling FL Studio instruments.