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Hernando de Soto faced several challenges during his exploration of North America, including harsh and unfamiliar terrain, hostile encounters with Indigenous populations, and difficulties in securing food and supplies for his expedition. Additionally, the lack of support from Spain and the challenges of maintaining troop morale further complicated his journey. De Soto's ambition to find gold and establish a Spanish presence in the region led to significant hardships, ultimately culminating in his death without achieving his primary goals.

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