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The Calculate in Excel updates all formulas in cells to run their calculations. Normally this is done automatically every time you make any change in your worksheet, such as typing in a new number. All formulas are recalculated, so that your new figure's impact on the worksheet will be accounted for. It is possible to have calculations happen only when the user wants, by using manual calculation. Then the user can type in lots of figures, without the worksheet updating its formula results after every new figure. It is not often used but can be useful when the users want to see the impact of different changes actually happening.

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