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There is no single formula that can be said to be the best. Every calculation you do is different and there are different ways in Excel to do the same calculation. It will depend on the calculation you want. So the question cannot really be answered. Generally you can use the plus(+), minus(-), multiply(*) and divide(/) operators in Excel and they would be used in basic mathematical calculations. Functions like SUM can also be used to do some basic calculations.

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