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That depends on the context of the sentence in which you are using them. If for example you are suggesting that you and another should go somewhere, the correct use would be "you and I." As in: You and I should go to the gas station. On the other hand, if you and your friend are the receiver of the action, the correct useage would be "you and me." As in: That car almost hit you and me.

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16y ago

What else can I help you with?