The halfway point between Des Moines, Iowa, and Wilmington, Delaware, is approximately near the area of Columbus, Ohio. This location is roughly equidistant from both cities, making it a suitable stop for travelers. Depending on the specific route taken, alternative halfway points may vary slightly, but Columbus is a common reference.
Davenport, Ia
Brooklyn, Missouri.
Brule, NE
Stockton, IA
Gary, IN
Cincinnati, OH
West Des Moines, Iowa
Hillsdale, IL
Des Moines, IA
According to Google Maps - the halfway point would be somewhere close to Toledo, OH
== == The best I can calculate -- using my Rand McNally Route Planner -- is that the mid-point is at or near the town of Arispie, Iowa. Arispie is located about 54 miles SSW of Des Moines, Iowa, and about 90 miles SSE of Omaha, Nebraska. You can use meetways.com to find the exact mid point between 2 places.
The town that is roughly halfway between Des Moines, Iowa, and Monticello, Iowa, is Anamosa. Located along U.S. Route 151, Anamosa serves as a convenient stop for travelers between the two cities. It's known for attractions like the National Motorcycle Museum and historic sites.