The halfway point between Wheeling, West Virginia and Brooksville, Florida is Devils Cross Roads, SC.
Kissimmee appears to be centrally located, but if you were driving from the northern border to Key West, Port St. Lucie would be halfway.
The halfway point when driving from Pensacola, Florida, to Biddeford, Maine, is roughly around the area of Virginia or West Virginia, depending on your route. A common halfway point is near the town of Winchester, Virginia. This location is approximately 600 miles from both starting points, making it a convenient stop for travelers.
The halfway point between New Smyrna Beach and Key West would be somewhere in West Palm Beach. The exact town I do not know but this is your midpoint.
Brunswick, Georgia would be the Halfway point, but many would choose Savannah, Georgia an hour and a half north of Brunswick for the amenities.
West Union, Iowa is the halfway point.
The halfway point between Miami, Florida and Atlanta, Georgia is Gainesville, Florida. The exact location is the 43rd street Deli and Breakfast at 3483 South West Willison Road in Gainesville.
Just west of Fayetteville, North Carolina.
The Atchafalaya Basin Bridge in Maringouin, LA, but anything west of Baton Rouge would be OK.
The city that is approximately halfway between Vero Beach and Rotonda West, Florida, is Port Charlotte. This city is located along the Gulf Coast and offers various amenities and recreational options. It serves as a convenient meeting point for travelers coming from either direction.
Grantsville, MD is the closest town to the halfway point on the route.
The halfway point is Price, NC.