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The question as posed is unanswerable since it does not specify the what "southwest" is in relation to.

If it is about the Southwestern USA, then the answer is Hernando de Soto.

If it is about the Southwest Andean Region, then the answer is Francisco Pizarro.

If it is about Southwestern edge of the Gulf of Mexico, then the answer is Hernan Cortés.

Ad nauseum.
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