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Files (not critical to running programs)yes. Programs no.
(There are a bunch of registry files that usually need to be set which happens when you install a program (that's one of the reasons it takes so long)) these Registry files have information on the paths to the program files so if you move the program files the registry entries will not find the program files and the program will not work.
Uninstall the programs and reinstall pointing to the other disk as location (some programs will not let you do this so you are stuck!)
Some programs that are just a single .exe file will be movable.

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15y ago

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