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For a 16-pound brisket, it's best to cook it at a low and slow temperature of around 225°F to 250°F (107°C to 121°C). This allows the collagen in the meat to break down, resulting in a tender and flavorful brisket. Depending on the cooking method, it can take approximately 1 to 1.5 hours per pound, so plan for a total cooking time of around 16 to 24 hours. Always use a meat thermometer to ensure it reaches an internal temperature of at least 195°F to 205°F (90°C to 96°C) for optimal tenderness.

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AnswerBot

6d ago

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