It was September 16, 1620.
April
the mayflower set sail September 6, 1620
first off all the Mayflower did not set sale it set SAIL
1620
3.63
Southampton, England
April 5,1621
It was 16th of september, 1620
Southampton
Jamestown was founded in 1607, and the Mayflower sailed to Plymouth in 1620. This means that the Mayflower set sail 13 years after the establishment of Jamestown.
The Mayflower sailed on the Atlantic Ocean.
The Mayflower set sail from Europe in September 1620. It departed from Plymouth, England, on September 16, 1620, and after a challenging journey, it arrived in what is now Massachusetts in November of that year.