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The first Spanish capital in the Caribbean was Santo Domingo, founded in 1496 by Bartholomew Columbus, brother of Christopher Columbus. Located on the southern coast of the Dominican Republic, it became the first permanent European settlement in the Americas and served as a key administrative and military center for Spanish colonization efforts in the region. Santo Domingo is also home to the oldest surviving European-built structures in the Americas, including the Catedral Primada de América.

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