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American westward expansion significantly impacted the lives of the Cherokee by leading to their forced removal from ancestral lands through policies like the Indian Removal Act of 1830. This culminated in the tragic Trail of Tears, where thousands of Cherokee were relocated to designated Indian Territory, suffering immense hardships and loss of life. The disruption of their traditional way of life and governance marked a profound cultural and social upheaval for the Cherokee Nation. Ultimately, westward expansion contributed to the erosion of their sovereignty and the fragmentation of their communities.

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