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The earliest use of the word was from about 1807; it is probably from the Dutch word "doop", which means "thick liquid or paste". Its association with drugs may have come from the practice of smoking opium that had a pasty, semi-liquid texture. At some point the word dope came to mean inside information as in "what's the dope on the second race?" in which horses may have been drugged ( or "doped") to alter the race's outcome.

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