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In many cases, amount matters. Very small amounts of some toxic substances may make you ill without killing you, and small enough amounts might not even be noticed. Some toxic substances build up over time until a lethal concentration is reached in the body; no single tiny ingestion causes illness or death.

So the affect a substance will have depends on the substance and on the amount ingested.

When it comes to poisons or toxic materials we always must think back to Paracelsus (1493 - 1541) the Swiis German Renaissance scientist who observed in his study ox toxicology that "All things are poison, it depends only on the dose" In the case of this question all chemicals (that would be everything in the world) is toxic if you have n overdose. This would include materials generally thought to be beneficial like water, oxygen, vitamins, iron, and so on. Some materials are toxic at lower doeses, others at higher.

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