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How is class 1 mhc involved in organ donation situations or bone marrow transfer?
MHC class 1 receptors have different genes encoding it: HLA-A, HLA-B and HLA-C. Each gene come in two versions, mom and dad, so that is a total of 6 possibilities.
MHC is highly polygenic and polymorphic. HLA-A has 59 alleles, HLA-B has 111 alleles and HLA-C has 37 alleles. 59*111*37*6*2 = ~3 million combination. The odds that you will exactly match the same alleles as a donor is almost none. So they try to match several of the most important ones and even then it is very difficult. If your MHC's don't match well the organ receiver's adaptive immunity (specifically T cells) will recognize the transplanted organ as foreign and reject it.
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What is a yellow marrow?
Yellow marrow is the type of bone marrow found in the central cavities of long bones of adults. It is mainly composed of fat cells and serves as a fatty reserve for energy storage. Yellow marrow can convert to red marrow in certain situations, such as during periods of increased blood cell production.
How can one donate bone marrow?
The National Marrow Donation Program website gives details on how one can sign up as a potential donor. Around 1 in 500 program members go on to donate marrow.
Where can one find information on bone marrow donors in Canada?
Information on bone marrow donation in Canada can be viewed at the website of the Canadian Blood Services. There is a comprehensive FAQ section which should answer many of your questions.
What is involved in donating bone marrow and what are the odds of a match?
Their are many things that are involved in donating bone marrow. Some things that are involved are money, blood and many more. The odds of a match are less than 25 %.
What does red marrow do and where is it found?
Red bone marrow is found in ribs , ends of long bones and is involved in RBC production .
Which is involved in red blood cell production?
Bones or Bone Marrow
What are the 2 types of marrow found in the bone?
The red bone marrow makes red blood cells. The yellow bone marrow makes chemical energy.
What are the organs involved in the lympathic system?
Red Bone Marrow and thymus gland
What are blood cells involved in clotting?
Platelets are involved in blood clotting. They are also called thrombocytes and come from the bone marrow.
How is bone marrow donated?
Giving a person bone marrow allows them to make more red blood cell or white blood cells. Bone marrow is the ingredients to making these products. The circulatory uses the bone marrow from a donor.
How has Leighton Meester helped the community?
Leighton Meester has supported:- ONE Campaign Charity (AIDS, Poverty)- DKMSCauses:- Blood, Marrow & Organ Donation- Cancer
Where can one make a cord blood donation?
You simply register with the national marrow donor program and then the cord will be taken after labor at the hospital where you give birth to your child.
