Nowadays, it's really quite hard to kill yourself with pills. Unlike 40 years ago, there are very few synergistic interactions or individual medications even remotely accessible to the public that are lethal, fast, painless, sure, calm. In specific answer to your question, unless you're a Doctor Who can prescribe really exotic meds and knows exactly how to use them -- No.
If you have actual MDMA it is fairly hard to overdose, you would have to set out to do it. The LD50 for MDMA is 80mg/kg. Note that most pills sold as ecstasy don't contain MDMA but most likely contain amphetamines or research chemicals (i.e mephedrone or MDPV)
It's quite easy to overdose on it, yes. It's also very dangerous.
easy (calm)... easy :L
easy going, calm, relaxed
Caffeine increases your blood pressure and heart rate. It stimulates the cardiovascular system. If too much caffeine is present, it can stimulate the heart to the point of ventricular fibrillation, which can lead to rapid cardiac arrest and death. It is very difficult to overdose on caffeine using coffee, but caffeine pills are easy to overdose on and deaths have been reported from caffeine pills. They should be used with caution. One or two of the average caffeine pill should be enough for most people to get a coffee-like buzz.
VERY painful. It is also very easy to become infected. See a doctor.
cool, casual, calm, easy, unemotional, neutral
insensible, unexcitable, calm, passive, easy
the answer is easy eat frosted flakes.
No, it is a very painful procedure that requires a lot of money.
Chill out Relax Chillax Calm down
they were calm and easy to train