Can wellbutron XL and fentermine and topamax be taken together?

Answer 1

The following does not take the place of advice from your pharmacist or doctor. This is from the Drug interaction checker at Drugs.com.

Note from the Author: This answer has been provided by a medical professional, but not a medical doctor. The advice or answer located above should NOT take the place of your primary care physician's medical advice. Furthermore, this answer has been provided in accordance with WikiAnswers and Answers.com disclaimers and policies. Do not reveal personal information within questions, as this is an anonymous service. In an emergency, get off the computer and dial 911 or your local emergency number. Contact your physician's exchange (usually provided through his/her office number) if you have questions or concerns after business hours. The author of this answer is not responsible for misguided or misinformed attempts to follow this advice. ALWAYS ask your doctor if you have questions or concerns about your or your child's health and do not use WikiAnswers as a substitute for proper medical advice and care provided by your personal physician. buPROPion and phentermine (Major Drug-Drug) MONITOR CLOSELY: The use of bupropion is associated with a dose-related risk of seizures. The estimated incidence of seizures is approximately 0.1% at dosages up to 300 mg/day and 0.4% at dosages between 300 to 450 mg/day, but increases almost tenfold between 450 mg and 600 mg/day. The risk may also be increased during coadministration with selective serotonin reuptake inhibitors (SSRI antidepressants or anorectics), monoamine oxidase inhibitors, neuroleptic agents, central nervous system stimulants, opioids, tricyclic antidepressants, other tricyclic compounds (e.g., cyclobenzaprine, phenothiazines), systemic steroids, and/or any substance that can reduce the seizure threshold (e.g., carbapenems, cholinergic agents, fluoroquinolones, interferons, chloroquine, mefloquine, lindane, theophylline). These agents are often individually epileptogenic and may have additive effects when combined.

MANAGEMENT: Extreme caution is advised if bupropion is administered with any substance that can reduce the seizure threshold, particularly in the elderly and in patients with a history of seizures or other risk factors for seizures (e.g., head trauma; brain tumor; severe hepatic cirrhosis; metabolic disorders; CNS infections; excessive use of alcohol or sedatives; addiction to opiates, cocaine, or stimulants; Diabetes treated with oral hypoglycemic agents or insulin). Bupropion as well as concomitant medications should be initiated at the lower end of the dose range and titrated gradually if feasible. The total dose of bupropion should generally not exceed 450 mg/day (or 150 mg every other day in patients with severe hepatic cirrhosis). Bupropion should be discontinued and not restarted in patients who experience a seizure during treatment.

buPROPion and topiramate (Moderate Drug-Drug) MONITOR: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.

MANAGEMENT: During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.