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Na+ and K+ are both important in primary active transport - e.g. the sodium potassium pump. This establishes a voltage and concentration gradient outside of our cell membranes that can then be used for "work" like bringing glucose into the cell via the Na+/glucose cotransporter.

Cl- is a large intracellular anion that also helps to keep the inside of a cell negatively charged in relation to the extracellular fluid. So again, it helps create a voltage difference so that work can be done more easily.

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