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The original answer posted was Cholecystokinin, which is actually a peptide hormone that is released to inhibit gastric mobility. But it is not the first hormone to be released when fat or food initially contacts the duodenum.When Fat enters the duodenum, this accounts for the third phase of gastric secretion, called intestinal phase. This phase accounts for 5% of the total secretory response. It begins when food leaves the stomach and enters the small intestine (duodenum). When the food first contacts the intestinal wall, it stimulates intestinal cells to release a hormone called, intestinal gastrin, that enhances gastric gland secretion.

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