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If you start taking a good B12 vitamin, you should notice a difference within a week or two. Your memory will improve, and so will your energy. Depression may disappear, and take a variety of cravings along with it. If you had any gastrointestinal issues with the lack of B12, those should clear up. In addition, you'll start feeling better overall, the opposite of that "general malaise" that is so often used to describe diseases. But it has to get into your bloodstream.

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