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Industrial workers who are exposed to manganese dust may develop nervous system problems similar to Parkinson's disease. Symptoms of manganese toxicity do not usually appear even at high levels of dietary intake; however, in severe cases of excessive manganese consumption, humans can develop a syndrome called "manganese madness," characterized by hallucinations, violent acts, and irritability. Over-consumption of manganese is also associated with impotence. Manganese toxicity is most likely to occur in people with chronic liver disease, because your liver plays an important role in eliminating excess manganese from your body. In 2000, the Institute of Medicine at the National Academy of Sciences established the following Tolerable Upper Intake Levels (UL) for manganese of 11 milligrams for adults.

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