anxiety, worry, sorrow, irritation, suffering, pain
agitate, disturb, distress
"Disaster" is probably the closest synonym, but "distress" rather close.
Distress can be a synonym for 'disappointment'
A synonym for "equanimity" is levelheadedness. An antonym for "equanimity" is discomposure. Please see the related link below.
A synonym for flinch is "wince," which refers to a quick, involuntary movement as a reaction to pain or distress.
affliction, grief, anguish, distress, agony, heartbreak, sadness, misery
affliction, grief, anguish, distress, agony, heartbreak, sadness, misery
very bad luck, plain distraught
Tremble, quiver, shudder, agitate, rattle, upset, distress, undermine, weaken...
torture, struggle, strain, worry, afflict, distress, hurt, disturb, writhe, pain
A synonym for disaster is "catastrophe." Other alternatives include "calamity," "tragedy," and "misfortune." Each of these terms conveys a sense of significant damage or distress resulting from an unfortunate event.
* agony * distress * desolation * heartache * sorrow * anguish * misery * wretchedness