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The regulation that defines the occurrence of an action or situation as a serious incident is typically outlined in the relevant national or international safety and operational standards specific to the industry in question. For instance, in aviation, the International Civil Aviation Organization (ICAO) provides guidelines that classify serious incidents, while in healthcare, the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) has criteria for serious events. These definitions focus on the potential for significant harm or the actual occurrence of severe outcomes.

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