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Hemolytic crisis occurs from the rapid destruction of large numbers of red blood cells (hemolysis). The destruction occurs much faster than the body can produce new red blood cells.
Alternative NamesHemolysis - acute
ConsiderationsA hemolytic crisis causes acute (and often severe) anemia, because the body cannot make enough red blood cells to replace those that are destroyed. The part of red blood cells that carries oxygen (hemoglobin) is released into the bloodstream, which can lead to kidney damage.
Common CausesThere are many causes of hemolysis, including:
- A lack of certain enzymes inside red blood cells
- Autoimmune diseases
- Certain infections
- Defects in the hemoglobin molecules inside red blood cells
- Defects of the proteins that make up the internal framework of red blood cells
- Medication side effects
- Reactions to blood transfusions
Many of these conditions can lead to a hemolytic crisis.
Call your health care provider ifIf you have any of the following symptoms, contact your doctor:
- A decrease in the amount of urine you produce
- Fatigue, pale skin, or other symptoms of anemia, especially if these symptoms get worse
- Urine that looks red, red-brown, or brown (tea-colored)
Emergency treatment may be necessary. This may include a hospital stay, oxygen, blood transfusions, and other treatments.
When your condition is stable, your doctor will perform a physical examination and ask questions, such as:
- When did you first notice symptoms?
- What symptoms did you notice?
- Do you have a history of hemolytic anemia, G6PD deficiency, or a kidney disorder?
- Does anyone in your family have a history of hemolytic anemia or abnormal hemoglobin proteins?
The physical examination may occasionally show swelling of the spleen (splenomegaly).
Tests may include:
- Blood chemistrypanel
- Complete blood count (CBC)
- Coombs' test
- Kidney or abdominal CT scan
- Kidney or abdominal ultrasound
- Serum free hemoglobin
- Urine free hemoglobin
Schwartz RS. Autoimmune and intravascular hemolytic anemias. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 164.
Golan DE. Hemolytic anemias: red cell membranes and metabolic defects. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 165.
Gregg XT, Prchal JT. Red blood cell enzymopathies. In: Hoffman R, Benz EJ, Shattil SS, et al., eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 45.
Gallagher PG, Jarolim P. Red blood cell membrane disorders. In: Hoffman R, Benz EJ, Shattil SS, et al., eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 46.
Powers A, Silberstein LE. Autoimmune hemolytic anemia. In: Hoffman R, Benz EJ, Shattil SS, et al., eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 47.
Schrier SL, Price EA. Extrinsic nonimmune hemolytic anemias. In: Hoffman R, Benz EJ, Shattil SS, et al., eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 48.
What else can I help you with?
What is the average that hemolysis kills people?
Hemolysis itself does not typically kill people. However, severe hemolysis can result in complications such as kidney damage, anemia, or hemolytic crisis, which can be life-threatening if not treated promptly. The outcome depends on the underlying cause of hemolysis and how quickly it is diagnosed and managed.
What is the financial bailout package crisis?
There is no such crisis as the financial bailout package crisis. the bailout was created to overcome the financial crisis.
When will the crisis over?
You have to be more specific when you are talking about "crisis". Do you mean the economic crisis?
Is crisis an adverb?
Crisis is a noun. As an adjective, when referring to, or for the use in dealing with a crisis
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Why did the financial crisis occur in 2008?
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Is the word crisis singular or plural?
The word crisis is singular. The plural form of crisis is crises.
Language did the word crisis come from?
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What was the largest crisis of Bush?
The Housing Crisis.
What is a synonym for crisis?
a synonym for crisis: disaster.
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A crisis is a word categorized as being a noun. Therefore, one can say "I had a mid life crisis", or "The crisis was averted".
