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The reason fluid leaves at the arterial end of the capillary bed and returns to the venous end of the capillary bed is the difference in hydrostatic pressure. This means the pressure against the inside of the vessel is greater that the pressure on the outside of the vessel on the arterial end and vice-versa on the venous end. Also, loss of water at the arterial end very slightly raises the oncotic pressure on the venous end, although to what degree this adds to the return of fluid to the vasculature is unknown.

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