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The Interstate Commerce Commission (ICC), established in 1887, primarily regulated railroads and later expanded to oversee other forms of interstate commerce. While it did not directly regulate the sale of whiskey, the ICC's regulations on transportation could indirectly affect the whiskey trade, particularly in terms of shipping and distribution across state lines. Thus, while not directly related to whiskey sales, the ICC's role in regulating transportation impacted the broader commerce environment in which whiskey was sold in the Midwest.

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