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A functional group may react differently, but does not always do so. One of the well known examples is a hydroxyl group, which ionizes sufficiently to act as a weak acid when the hydroxyl group is bonded directly to a carbon atom that is part of an aromatic ring, but not when the hydroxyl group is attached to a carbon that is part of an aliphatic chain.

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Q: Does the functional group react differently depending on the carbon backbone?
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