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Whenever an acid reacts, it does so by transfering an H+ ion (also known as a proton) over to a base. In other words the abillety to react with an acid is defined by the reciving molecules abillety to receive a proton. This goes for all bases, water and a few other substences. And so the answer to the question is yes, the abillety to react with an acid leads to a chemical change, so do all other reactions between molcules.

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