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Oxygen is an extremely electronegative element. It acts as the final electron acceptor for the electron transport chain in cellular respiration. The electron transport chain is required to process NADH and FADH2. Oxygen also increases the proton concentration gradient across the mitochondria inner membrane. Without oxygen to accept the Hydrogen ions and form H2O, cellular respiration stops. Oxygen is vital to the Citric Acid cycle to recycle the H+ ions. Therefore, if oxygen is removed, the body begins using anaerobic processing of NADH. Glycolysis requires NAD+, yet without aerobic respiration NADH can not be converted back to NAD+.

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